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Use of metronidazole in malnourished children

This question was posted the Prevention and treatment of severe acute malnutrition forum area and has 2 replies. You can also reply via email – be sure to leave the subject unchanged.

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Anonymous 360

Consultant

Normal user

2 Aug 2011, 20:43

A programme in Sudan has discontinued prescription of metronidazole for malnourished children on account of some study done in south America indicating it does more harm than good in malnourished children in need of this medication especially for treating diarrhea with mucus/blood. I need more accurate information on metronidazole and if indeed its no longer recommended for malnourished children, what other options are available?
Thanks.
MK

Jay Berkley

Frequent user

2 Aug 2011, 22:54

Do you have a reference to the South American study?

The only actual trial I have seen is this: http://www.ncbi.nlm.nih.gov/pubmed/8458314 & http://www.ncbi.nlm.nih.gov/pubmed/8458315 but it was not compared to amoxicillin or benzyl penicillin plus gentamicin.

There is a small Mexican pharmacokinetic study suggesting dosage may need to be adjusted in malnutrition: http://www.ncbi.nlm.nih.gov/pubmed/8460335

jay

Tamsin Walters

en-net moderator

Forum moderator

24 Aug 2011, 20:16

From Mordecai:

Hi Jay,
Thank you for your feedback.

Let me contact my colleague aforementioned study.

Mordecai


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