Research advisor in Health & Nutrition
Normal user
18 Aug 2011, 10:35
Is it correct to consider that catch up growth in a SAM child (marasmus) is very high then slows down as the child recuperates?
Hence is it correct to consider that nutritional requirements for a SAM child progressively diminish once the child recuperates from SAM to MAM and back to "normal"?
Globally I would be interested in any information describing the catch up growth of SAM children !
Thanks a lot
Frequent user
18 Aug 2011, 12:48
Just to clarify ... what do you mean by "catch-up growth"?
I have data on response to treatment for weight and MUAC. Response (in responders) tends to follows a typical growth curve with a rapid response followed by slower consolidation. This is the sort of curve we see in other fields (e.g. return of foveal sensitivity after retinal re-attachment surgery). I see this in both weight and MUAC. Is this what you mean?
retired
Normal user
18 Aug 2011, 13:27
Yes, this is correct. It is due to the different composition of the tissue that is laid down during catch-up (measured by impedence) - at first there is mainly lean tissue, which contains a higher water content during active protein synthesis - as the weight approaches normality the lean tissue is less hydrated and more fat is laid down. This process continues right up to around median weght-for-height where the exponential fall in rate of weight gain reaches an asymptote. You will not see this in many children as they are usually discharged at -1.5Z and so the final portion of the curve will not be observed. There is no change in the ratio of essential nutrients required during catch up - but there is a progressive reduction in the essential-nutrient to energy (nutrient density) needed. F100/RUTF is formulated to provide the required nutrients for rapid catch up with appropriate lean/fat tissue synthesis throughout recovery If CSB/family plate etc is given along with F100.RITF it slows the rate of catch up and there is a change in the ratio of lean/fat laid down so that insufficient functional tissue is made and although the children gain weight (less efficiently) they do not return physiologically or immunologically to normal.